{"id":301,"date":"2025-12-28T10:39:12","date_gmt":"2025-12-28T08:39:12","guid":{"rendered":"https:\/\/hala-care.com\/articles\/losing-weight-in-midlife-may-have-a-hidden-brain-cost\/"},"modified":"2025-12-28T10:39:12","modified_gmt":"2025-12-28T08:39:12","slug":"losing-weight-in-midlife-may-have-a-hidden-brain-cost","status":"publish","type":"post","link":"https:\/\/hala-care.com\/articles\/losing-weight-in-midlife-may-have-a-hidden-brain-cost\/","title":{"rendered":"Losing weight in midlife may have a hidden brain cost"},"content":{"rendered":"

Weight loss restored healthy metabolism in both young and mid-aged mice, but the brain told a different story. In mid-aged animals, slimming down actually worsened inflammation in a brain region tied to appetite and energy balance. While this inflammation eventually subsided, brain inflammation has been linked to cognitive decline and neurodegenerative disease. The results suggest that weight loss in midlife may not be as straightforward as once thought.<\/p>\n","protected":false},"excerpt":{"rendered":"

Weight loss restored healthy metabolism in both young and mid-aged mice, but the brain told a different story. In mid-aged animals, slimming down actually worsened…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-301","post","type-post","status-publish","format-standard","hentry","category-blog"],"yoast_head":"\nLosing weight in midlife may have a hidden brain cost - \u0645\u0643\u062a\u0628\u0629 \u0647\u0644\u0627 \u0643\u064a\u0631 \u0627\u0644\u0637\u0628\u064a\u0629<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hala-care.com\/articles\/losing-weight-in-midlife-may-have-a-hidden-brain-cost\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Losing weight in midlife may have a hidden brain cost - \u0645\u0643\u062a\u0628\u0629 \u0647\u0644\u0627 \u0643\u064a\u0631 \u0627\u0644\u0637\u0628\u064a\u0629\" \/>\n<meta property=\"og:description\" content=\"Weight loss restored healthy metabolism in both young and mid-aged mice, but the brain told a different story. In mid-aged animals, slimming down actually worsened...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hala-care.com\/articles\/losing-weight-in-midlife-may-have-a-hidden-brain-cost\/\" \/>\n<meta property=\"og:site_name\" content=\"\u0645\u0643\u062a\u0628\u0629 \u0647\u0644\u0627 \u0643\u064a\u0631 \u0627\u0644\u0637\u0628\u064a\u0629\" \/>\n<meta property=\"article:published_time\" content=\"2025-12-28T08:39:12+00:00\" \/>\n<meta name=\"author\" content=\"abdelghany1191\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"abdelghany1191\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/hala-care.com\/articles\/losing-weight-in-midlife-may-have-a-hidden-brain-cost\/\",\"url\":\"https:\/\/hala-care.com\/articles\/losing-weight-in-midlife-may-have-a-hidden-brain-cost\/\",\"name\":\"Losing weight in midlife may have a hidden brain cost - \u0645\u0643\u062a\u0628\u0629 \u0647\u0644\u0627 \u0643\u064a\u0631 \u0627\u0644\u0637\u0628\u064a\u0629\",\"isPartOf\":{\"@id\":\"https:\/\/hala-care.com\/articles\/#website\"},\"datePublished\":\"2025-12-28T08:39:12+00:00\",\"author\":{\"@id\":\"https:\/\/hala-care.com\/articles\/#\/schema\/person\/e4d08bd5eb82a6f0d6a868794ba2c82e\"},\"breadcrumb\":{\"@id\":\"https:\/\/hala-care.com\/articles\/losing-weight-in-midlife-may-have-a-hidden-brain-cost\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/hala-care.com\/articles\/losing-weight-in-midlife-may-have-a-hidden-brain-cost\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/hala-care.com\/articles\/losing-weight-in-midlife-may-have-a-hidden-brain-cost\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/hala-care.com\/articles\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Losing weight in midlife may have a hidden brain cost\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/hala-care.com\/articles\/#website\",\"url\":\"https:\/\/hala-care.com\/articles\/\",\"name\":\"\u0645\u0643\u062a\u0628\u0629 \u0647\u0644\u0627 \u0643\u064a\u0631 \u0627\u0644\u0637\u0628\u064a\u0629\",\"description\":\"\u0623\u0643\u062b\u0631 \u0645\u0646 10,000 \u0645\u0642\u0627\u0644 \u0637\u0628\u064a \u0645\u062a\u062e\u0635\u0635\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/hala-care.com\/articles\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/hala-care.com\/articles\/#\/schema\/person\/e4d08bd5eb82a6f0d6a868794ba2c82e\",\"name\":\"abdelghany1191\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/hala-care.com\/articles\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/ed77ddfef8dc7d2976ef35085ac6560537fa070e324fb278e56ca13b7016de34?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/ed77ddfef8dc7d2976ef35085ac6560537fa070e324fb278e56ca13b7016de34?s=96&d=mm&r=g\",\"caption\":\"abdelghany1191\"},\"sameAs\":[\"https:\/\/hala-care.com\"],\"url\":\"https:\/\/hala-care.com\/articles\/author\/abdelghany1191\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Losing weight in midlife may have a hidden brain cost - \u0645\u0643\u062a\u0628\u0629 \u0647\u0644\u0627 \u0643\u064a\u0631 \u0627\u0644\u0637\u0628\u064a\u0629","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/hala-care.com\/articles\/losing-weight-in-midlife-may-have-a-hidden-brain-cost\/","og_locale":"en_US","og_type":"article","og_title":"Losing weight in midlife may have a hidden brain cost - \u0645\u0643\u062a\u0628\u0629 \u0647\u0644\u0627 \u0643\u064a\u0631 \u0627\u0644\u0637\u0628\u064a\u0629","og_description":"Weight loss restored healthy metabolism in both young and mid-aged mice, but the brain told a different story. 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