{"id":1359,"date":"2026-08-23T18:15:41","date_gmt":"2026-08-23T15:15:41","guid":{"rendered":"https:\/\/hala-care.com\/articles\/a-major-alzheimers-risk-gene-may-shrink-brain-cells-years-before-symptoms\/"},"modified":"2026-08-23T18:15:41","modified_gmt":"2026-08-23T15:15:41","slug":"a-major-alzheimers-risk-gene-may-shrink-brain-cells-years-before-symptoms","status":"publish","type":"post","link":"https:\/\/hala-care.com\/articles\/a-major-alzheimers-risk-gene-may-shrink-brain-cells-years-before-symptoms\/","title":{"rendered":"A major Alzheimer\u2019s risk gene may shrink brain cells years before symptoms"},"content":{"rendered":"

Researchers have uncovered a possible reason why the Alzheimer\u2019s risk gene APOE4 can disrupt the brain long before memory problems begin. In mice, APOE4 increased a protein called Nell2, shrinking neurons and making memory circuits unusually active. That early hyperactivity predicted worse memory later in life. Reducing Nell2 in adult mice reversed the abnormal changes, raising hopes for a new way to intervene before Alzheimer\u2019s progresses.<\/p>\n","protected":false},"excerpt":{"rendered":"

Researchers have uncovered a possible reason why the Alzheimer\u2019s risk gene APOE4 can disrupt the brain long before memory problems begin. In mice, APOE4 increased…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1359","post","type-post","status-publish","format-standard","hentry","category-blog"],"yoast_head":"\nA major Alzheimer\u2019s risk gene may shrink brain cells years before symptoms - \u0645\u0643\u062a\u0628\u0629 \u0647\u0644\u0627 \u0643\u064a\u0631 \u0627\u0644\u0637\u0628\u064a\u0629<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hala-care.com\/articles\/a-major-alzheimers-risk-gene-may-shrink-brain-cells-years-before-symptoms\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A major Alzheimer\u2019s risk gene may shrink brain cells years before symptoms - \u0645\u0643\u062a\u0628\u0629 \u0647\u0644\u0627 \u0643\u064a\u0631 \u0627\u0644\u0637\u0628\u064a\u0629\" \/>\n<meta property=\"og:description\" content=\"Researchers have uncovered a possible reason why the Alzheimer\u2019s risk gene APOE4 can disrupt the brain long before memory problems begin. 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