{"id":1322,"date":"2026-08-15T13:55:39","date_gmt":"2026-08-15T10:55:39","guid":{"rendered":"https:\/\/hala-care.com\/articles\/scientists-solve-the-mystery-of-a-brain-switch-that-can-trigger-weight-loss-in-opposite-ways\/"},"modified":"2026-08-15T13:55:39","modified_gmt":"2026-08-15T10:55:39","slug":"scientists-solve-the-mystery-of-a-brain-switch-that-can-trigger-weight-loss-in-opposite-ways","status":"publish","type":"post","link":"https:\/\/hala-care.com\/articles\/scientists-solve-the-mystery-of-a-brain-switch-that-can-trigger-weight-loss-in-opposite-ways\/","title":{"rendered":"Scientists solve the mystery of a brain \u201cswitch\u201d that can trigger weight loss in opposite ways"},"content":{"rendered":"

Scientists have uncovered why two seemingly opposite ways of targeting the same brain receptor can both promote weight loss. In mice, activating the GIP receptor in the brainstem reduced appetite, while blocking it in the hypothalamus removed a kind of \u201cbrake\u201d on fullness signals. The discovery helps explain why very different obesity drugs can achieve similar results and suggests that carefully combining GIP-targeting treatments with GLP-1 drugs like those related to Wegovy and Ozempic could produce stronger effects.<\/p>\n","protected":false},"excerpt":{"rendered":"

Scientists have uncovered why two seemingly opposite ways of targeting the same brain receptor can both promote weight loss. In mice, activating the GIP receptor…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1322","post","type-post","status-publish","format-standard","hentry","category-blog"],"yoast_head":"\nScientists solve the mystery of a brain \u201cswitch\u201d that can trigger weight loss in opposite ways - \u0645\u0643\u062a\u0628\u0629 \u0647\u0644\u0627 \u0643\u064a\u0631 \u0627\u0644\u0637\u0628\u064a\u0629<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hala-care.com\/articles\/scientists-solve-the-mystery-of-a-brain-switch-that-can-trigger-weight-loss-in-opposite-ways\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scientists solve the mystery of a brain \u201cswitch\u201d that can trigger weight loss in opposite ways - \u0645\u0643\u062a\u0628\u0629 \u0647\u0644\u0627 \u0643\u064a\u0631 \u0627\u0644\u0637\u0628\u064a\u0629\" \/>\n<meta property=\"og:description\" content=\"Scientists have uncovered why two seemingly opposite ways of targeting the same brain receptor can both promote weight loss. In mice, activating the GIP receptor...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hala-care.com\/articles\/scientists-solve-the-mystery-of-a-brain-switch-that-can-trigger-weight-loss-in-opposite-ways\/\" \/>\n<meta property=\"og:site_name\" content=\"\u0645\u0643\u062a\u0628\u0629 \u0647\u0644\u0627 \u0643\u064a\u0631 \u0627\u0644\u0637\u0628\u064a\u0629\" \/>\n<meta property=\"article:published_time\" content=\"2026-08-15T10:55:39+00:00\" \/>\n<meta name=\"author\" content=\"abdelghany1191\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"abdelghany1191\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/hala-care.com\/articles\/scientists-solve-the-mystery-of-a-brain-switch-that-can-trigger-weight-loss-in-opposite-ways\/\",\"url\":\"https:\/\/hala-care.com\/articles\/scientists-solve-the-mystery-of-a-brain-switch-that-can-trigger-weight-loss-in-opposite-ways\/\",\"name\":\"Scientists solve the mystery of a brain \u201cswitch\u201d that can trigger weight loss in opposite ways - \u0645\u0643\u062a\u0628\u0629 \u0647\u0644\u0627 \u0643\u064a\u0631 \u0627\u0644\u0637\u0628\u064a\u0629\",\"isPartOf\":{\"@id\":\"https:\/\/hala-care.com\/articles\/#website\"},\"datePublished\":\"2026-08-15T10:55:39+00:00\",\"author\":{\"@id\":\"https:\/\/hala-care.com\/articles\/#\/schema\/person\/e4d08bd5eb82a6f0d6a868794ba2c82e\"},\"breadcrumb\":{\"@id\":\"https:\/\/hala-care.com\/articles\/scientists-solve-the-mystery-of-a-brain-switch-that-can-trigger-weight-loss-in-opposite-ways\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/hala-care.com\/articles\/scientists-solve-the-mystery-of-a-brain-switch-that-can-trigger-weight-loss-in-opposite-ways\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/hala-care.com\/articles\/scientists-solve-the-mystery-of-a-brain-switch-that-can-trigger-weight-loss-in-opposite-ways\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/hala-care.com\/articles\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Scientists solve the mystery of a brain \u201cswitch\u201d that can trigger weight loss in opposite ways\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/hala-care.com\/articles\/#website\",\"url\":\"https:\/\/hala-care.com\/articles\/\",\"name\":\"\u0645\u0643\u062a\u0628\u0629 \u0647\u0644\u0627 \u0643\u064a\u0631 \u0627\u0644\u0637\u0628\u064a\u0629\",\"description\":\"\u0623\u0643\u062b\u0631 \u0645\u0646 10,000 \u0645\u0642\u0627\u0644 \u0637\u0628\u064a \u0645\u062a\u062e\u0635\u0635\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/hala-care.com\/articles\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/hala-care.com\/articles\/#\/schema\/person\/e4d08bd5eb82a6f0d6a868794ba2c82e\",\"name\":\"abdelghany1191\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/hala-care.com\/articles\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/ed77ddfef8dc7d2976ef35085ac6560537fa070e324fb278e56ca13b7016de34?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/ed77ddfef8dc7d2976ef35085ac6560537fa070e324fb278e56ca13b7016de34?s=96&d=mm&r=g\",\"caption\":\"abdelghany1191\"},\"sameAs\":[\"https:\/\/hala-care.com\"],\"url\":\"https:\/\/hala-care.com\/articles\/author\/abdelghany1191\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Scientists solve the mystery of a brain \u201cswitch\u201d that can trigger weight loss in opposite ways - \u0645\u0643\u062a\u0628\u0629 \u0647\u0644\u0627 \u0643\u064a\u0631 \u0627\u0644\u0637\u0628\u064a\u0629","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/hala-care.com\/articles\/scientists-solve-the-mystery-of-a-brain-switch-that-can-trigger-weight-loss-in-opposite-ways\/","og_locale":"en_US","og_type":"article","og_title":"Scientists solve the mystery of a brain \u201cswitch\u201d that can trigger weight loss in opposite ways - \u0645\u0643\u062a\u0628\u0629 \u0647\u0644\u0627 \u0643\u064a\u0631 \u0627\u0644\u0637\u0628\u064a\u0629","og_description":"Scientists have uncovered why two seemingly opposite ways of targeting the same brain receptor can both promote weight loss. 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